Control of Shimadzu’s Nexera, Prominence series by Waters’ Empower chromatography data software is now available through a collaboration between Waters and Shimadzu utilizing the “Open Interface Portal (OIP)” for multi-vendor hardware control.
Nexera series - Options
Ultra High Performance Liquid Chromatograph
- Overview
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LabSolutions Chromatography Software
Extract the Smallest of Shoulder Peaks 
The i-PeakFinder tool can automatically recognize peaks even in complex chromatograms with high noise, and accounts for baseline drift for higher integration accuracy. Adjustable parameters in i-PeakFinder, such as peak detection threshold, allow the user to detect smaller peaks. In addition, the i-PDeA II function can quantify peaks that cannot be completely separated by a column. Separate peaks by simply specifying the time and wavelength in LabSolutions.
Consistent Peak Splitting
Manually setting the baseline for fused peaks is time-consuming, and the peaks may be split differently depending on the user. The i-PeakFinder has adjustable parameters for different analyses, allowing the consistent application of the best baseline in each situation.
It is important to use the most appropriate column in your LC system to achieve the highest efficiency and most accurate chromatograms. The Shim-pack series consists of a range of columns designed with the increased capabilities of the Nexera in mind. The superior ruggedness of Shim-pack columns ensures a long lifetime even with demanding sample matrices.
Shim-pack Velox™
The superficially porous particle (SPP) technology allows for optimum separation and analysis times. The range of column types available enables you to choose the most appropriate column for each application.
Shim-pack™ XR-ODS II & III
Although the Shim-pack XR-ODS II has a particle size of 2.2 μm, it can be used up to a pressure of 60 MPa, making it appropriate for a wide range of analyses. The particle size of the XR-ODS III column has been reduced to 1.6 μm. With a maximum pressure of 100 MPa, it achieves high separation even with a short column length.
These columns are suitable for shortening analysis times while taking full advantage of the high separation power of UHPLC.
Shim-pack™ GIS/GIST/GISS
The Shim-pack GIS/GIST/GISS series lineup includes columns with particle sizes ranging from 5 μm, appropriate for HPLCs, to 2 μm, appropriate for UHPLCs. With a variety of substrates available, they are ideal for method development.
| GIS Series: | HPLC columns packed with a high-purity silica gel material as a base. With high particle uniformity to secure the mobile phase path, these columns are ideal for low-pressure analysis. |
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| GIST Series: | An increase in the inertness of the silica results in improved peak shapes and ruggedness. Can be used in pH 1–10 environments. Easy to use for a wide range of chemicals and environments. |
| GISS Series: | Adding to the advantages of the GIST series, a faster elution time has been achieved to provide even sharper peaks. |
Shim-pack Scepter
Excellent stability and performance could be achieved under a wide range of LC conditions with Shim-pack Scepter LC columns, which are the next generation organic silica hybrid based columns. With different chemistry characteristics, Shim-pack Scepter columns are effective for method development/scouting with suitability for use in a wide variety of applications. With different particle sizes (1.9 μm, 3 μm, 5 μm) and different column dimensions, Shim-pack Scepter LC columns are fully scalable between UHPLC, HPLC and preparative LC making method transfer seamless between different laboratory instrumentation.
ANALYTICAL INTELLIGENCE
- Automated support functions utilizing digital technology, such as M2M, IoT, and Artificial Intelligence (AI), that enable higher productivity and maximum reliability.
- Allows a system to monitor and diagnose itself, handle any issues during data acquisition without user input, and automatically behave as if it were operated by an expert.
- Supports the acquisition of high-quality, reproducible data regardless of an operator’s skill level for both routine and demanding applications.
Drivers
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Control of Shimadzu’s Nexera and Prominence series by Thermo Scientific™ Dionex™ Chromeleon™ Chromatography Data System (CDS) Software (hereafter referred to as "Chromeleon™") 7 is now available through a collaboration between Thermo Fisher Scientific Inc. -
Control of Shimadzu’s Nexera and Prominence series by OpenLab CDS is now available by adoption of Agilent’s RC.
LabSolutions Series
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LabSolutions CS features an innovative operating environment and provides complete data management to ensure secure information in networked laboratories. -
LabSolutions DB has a data management function and is compliant with the ER/ES Regulations. It is optimally configured for customers using a PC.
Software Options
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GPC software has been added to the LabSolutions lineup.
Application Specific LC Systems
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The National Agriculture and Food Research Organization (NARO) and Shimadzu have been investigating fast, convenient, and accurate methods for analyzing foods' functional components for its research and social implementation purposes.
Related information
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Efficient, Easy to Use, Space Saving
Up to six fraction collectors can be connected simultaneously.
Compatible with many racks corresponding to the intended fraction volume.
Can accommodate up to 3,240 fractions (6 FRC-40s, 10 mm tubes). -
The comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation analysis... -
The Co-Sense series features automatic sample processing systems intended to improve the efficiency of LC-MS operations by automating complicated sample processing steps. -
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CRB-6A Chemical Reaction Box
This is used to detect post-column reactions, for example.
Temperature can be controlled to 150 °C. -
The CTO-20A is a forced air-circulation-type column oven. It can regulate the temperature in a range going from 10 deg. C above room temperature to 85 deg. -
Low noise, low drift and wide dynamic range assure proven performance of the Shimadzu VP series HPLC. -
Enhanced Sensitivity for Trace Analysis
The ELSD-LTII utilizes a high-efficiency LED and enhanced digital signal treatment to minimize noise and deliver optimum sensitivity for trace analysis. -
World-class sensitivity meets diverse needs
The excellent basic performance of the Prominence series is further enhanced by the RF-20A/RF-20Axs fluorescence detectors, which offer world-class sensitivity, excellent ease of maintenance, and validation support functions. -
High Pressure Switching Valve FCV-32AH
The FCV-32AH is a 2-position 6-port high pressure flow switching valve. -
Inheriting the stability and extensibility that are the strengths of the Prominence series, the new RID-20A model of differential refractive index detector is designed with a new reference-cell auto-purge feature and validation support function. -
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Effectively adsorb impurities in the mobile phase in order to reduce the time required for method development and impurity analysis. -
Reduces the Adsorption of Basic Compounds on the Surface of the Glass Vial -
With LabSolutions LCGC, both LC and GC systems are operated from the same software, enabling simultaneous control of multiple instruments from a single PC. -
Exact Mass Database for Endogenous Metabolites contains multiple ready-to-use methods for comprehensive analysis of metabolites with different properties. It is based on the successful LC/MS/MS Method Packages for Primary Metabolites, Cell Culture Profiling, Lipid Mediators, Short Chain Fatty Acids, and Bile Acids, and provides a comprehensive list of 470 metabolites with retention times and exact mass information. -
LabSolutions MD uses an “Analytical Quality by Design” (AQbD) approach for achieving efficient method development by designing analysis methods based on science and risk. -
The evaporative light scattering detector (ELSD) is a general-purpose universal detector that can even detect components with no UV absorption, such as carbohydrates, lipids, surfactants, and synthetic polymers. -
The new, integrated i-Series LC system maintains the excellent performance of its predecessor while addressing the need for automation efficiency. -
The LC-2030C NT is an integrated high-performance liquid chromatography system which prioritizes easy-to-use features for a smooth analysis experience. The intuitive touch-screen interface and stable column performance over many continuous injections ensure reliable data every time, whether you are an HPLC beginner or an expert.
Column replacement is a breeze with the Shim-pack™ NT-ODS slide-in column. Simply slot the monolithic column into place and it connects automatically, with no need for any tools and no risk of human error.
Remote data monitoring allows more flexibility in scheduling and work from home possibilities.
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The Nexera XS inert system offers the ideal solution for the separation of biomolecules by combining the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path, ensured by the absence of wetted metal surfaces and offering ultra-high resistance to corrosion. -
The National Agriculture and Food Research Organization (NARO) and Shimadzu have been investigating fast, convenient, and accurate methods for analyzing foods' functional components for its research and social implementation purposes.
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Nexera lite inert is a robust HPLC system that eliminates the risk of corrosion by high-salt mobile phases and sample adsorption onto metal surfaces. It improves the data quality of protein analysis in biological samples with superior reproducibility, without any special considerations for stable and long-term use.
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Shim-pack SUR-Na, a ligand exchange chromatography column, offers excellent performance by combining size exclusion mode and
sodium-based ligand exchange mode to provide superior separation of sugar components. Pure water can be used for the mobile
phase, resulting in less effort to prepare for the analysis.
Optional accessories
Solvent Delivery Unit
| Part Name |
Description
|
|---|---|
| Low-pressure gradient unit | Low-pressure gradient unit for LC-40D/40D XR/40D XS/40D X3 |
| Reservoir selection valve | Two-solvent switching unit to be incorporated in solvent delivery unit |
| FCV-11AL | The mobile phase switching valve of 3 flow lines that connects to solvent delivery unit (external) |
| FCV-11ALS | The mobile phase switching valve of 1 flow line that connects to solvent delivery unit (external) |
| Automatic rinsing kit | Automatic rinsing kit for plunger seal cleaning |
| Mixier/Inert mixer MR 20 μL | High-efficiency mixer/inert mixer for high-pressure gradient system (volume 20 μL) |
| Mixer MR 40 μL | High-efficiency mixer for high-pressure gradient system (volume 40 μL) |
| Mixer MR 100 μL | High-efficiency mixer for high-pressure gradient system (volume 100 μL) |
| Mixer MR 180 µL Ⅱ/ Inert mixer MR 180 µL |
High-efficiency mixer/inert mixer for high-pressure gradient system (volume 180 μL) |
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Mixer/Inert mixer MR 40 μL LPGE
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High-efficiency mixer/inert mixer for high-pressure gradient system (volume 40 μL) |
| Mixer/Inert mixer MR 300 μL LPGE | High-efficiency mixer/inert mixer for high-pressure gradient system (volume 300 μL) |
Autosampler
| Part Name | Description | |
|---|---|---|
| Sample loop | 50 μL | Sample loop for 50 μL injection (standard configuration of SIL-40 XR/40C XR/40C XS/40C X3) |
| 100 μL | Sample loop for 100 μL injection (standard configuration of SIL-40/40C) | |
| 500 μL |
Sample loop to increase the injection volume up to 500 μL (Connect sample loop 100 μL) |
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| 2000 μL | Sample loop to increase the injection volume up to 2 mL (Connect sample loop 100 μL) |
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| Dual-injection kit | Tubing kits for dual injection | |
| Sample loop for loop injection |
5 μL | Sample loop for loop injection mode (volume 5 μL) |
| 20 μL | Sample loop for loop injection mode (volume 20 μL) | |
| 50 μL | Sample loop for loop injection mode (volume 50 μL) | |
| 1.5 mL | Plate for 1.5 mL sample vial (54) | |
| Sample plate | 1 mL | Plate for 1 mL sample vial (84) |
| 4 mL | Plate for 4 mL sample vial (28) | |
| 10 mL | Plate for 10 mL sample vial (12) | |
| Identification labels |
For 96-well microplates |
Identification label affixed to the 96-well microtiter plate (100 set) |
| For 96-well deep-well plates |
Identification label affixed to the 96-well deep-well plate (100 set) | |
| For 384-well microplates |
Identification label affixed to the 384-well microtiter plate (100 set) | |
| For 384-well deep-well plates |
Identification label affixed to the 384-well deep-well plate (100 set) | |
Column Oven
| Part Name | Description | |
|---|---|---|
| Active pre-heater | Pre-heater device for thermostatting mobile phase before the column inlet | |
| Nexlock™ SS | ID 0.1 mm×600 mm | Finger-tight high-pressure fitting |
| ID 0.3 mm×600 mm | ||
| PEEK lining stainless steel tubing | ID 0.1 mmx600 mm | PEEK lining piping used on the column inlet side. |
| ID 0.3 mmx600 mm | ||
UV Detector / PDA Detector
| Part Name | Description |
|---|---|
| UHPLC cell | Flow cell for high-speed analysis (volume 8 μL) |
| Semi-micro cell | Flow cell for semi-micro analysis (volume 2.5 μL) |
| Conventional cell | Flow cell with the same cell volume (12 μL) as standard cell of SPD-20A and SPD-M20A |
| Inert cell | Inert-type flow cell with metal-less wetted parts |
| UHPLC inert cell | Inert type flow cell for UHPLC analysis that does not use metal for the wetted parts. (Cell volume is 8 µL) |
| Low-diffusion inert cell | Inert type low-diffusion flow cell that does not use metal for the wetted parts. (Cell volume is 2.5 μL) |
| Preparative cell | Preparative flow cell with variable optical path length |
| Micro flow cell | Flow cell for micro analysis (volume 0.21 μL) |
| Maximum pressure cell | High-pressure resisting flow cell for Nexera™ UC |
| Solvent recycle valve | Valve to recycle mobile phase by attaching to SPD-40/40V |
Valve
| Part Name | Description |
|---|---|
| FCV-DR | Drive unit and control board for incorporating valve into CTOs (1 FCV valve is required separately) |
| FCV-0206 | 2-position 6-port valve (Maximum pressure: 44 MPa) |
| FCV-0607 | 6-position 7-port valve (Maximum pressure: 44 MPa) |
| FCV-0206H | 2-position 6-port valve (Maximum pressure: 80 MPa) |
| FCV-0607H | 6-position 7-port valve (Maximum pressure: 80 MPa) |
| FCV-0206H3 | 2-position 6-port valve (Maximum pressure: 130 MPa) |
| FCV-0607H3 | 6-position 7-port valve (Maximum pressure: 130 MPa)6 |
| FCV-0206H2i | 2-position 6-port valve (Maximum pressure: 105 MPa) Please use it with PEEK tubing or PEEK lining stainless steel tubing The wetted parts are ceramic, DLC, and PEEK. Does not contain metal. |
| FCV-0607H2i | 6-position 7-port valve (Maximum pressure: 105 MPa) Please use it with PEEK tubing or PEEK lining stainless steel tubing. The wetted parts are ceramic, DLC, and PEEK. Does not contain metal. |
Others
| Part Name | Description |
|---|---|
| Mobile phase monitor (controller) |
MPM-40 controller to monitor remaining mobile phase in real-time
Up to six bottle holders can be connected |
| pH monitor | pHM-40 to monitor mobile phase pH in real-time. |
| Reservoir tray | Reservoir tray for up to 8 bottles (1L) |
| AD board | Board for analog–digital conversion. It takes in detector signals as analog signals. |
| Optical cable connector expansion board |
The board to expand the number of optical cable connector channels to 12ch from 8ch (standard) by attaching to SCL-40/CBM-40 |
- Overview
- Features
- Applications
- Specs
- Downloads
- Configuration
- Columns
- Consumables
- Options
- Case Studies
- Support