Mycotoxins are highly toxic chemical byproducts from fungi commonly found in crops, and residual content in foods are regulated the world over.
LCMS-8060 - Options
High Performance Liquid Chromatograph Triple Quadrupole Mass Spectrometer
Newly Designed Ionization Unit
Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS units, allowing for easy maintenance.
IonFocus unit
A newly-developed ESI probe with focus electrodes introduces ions into the mass spectrometer more effciently, while expelling contaminants to reduce noise and provide more stable data. In addition, an improved heat-assist design promotes the ionization of a wide range of compounds. (Patented technology.) A new heat-assisted design improves the desolvation efficiency and dramatically enhances the sensitivity for challenging molecules such as steroid hormones.
Superior robustness
The excellent robustness of the LCMS-8060NX can be seen most clearly during consecutive analyses of samples of biological origin that tend to contaminate instruments. We performed consecutive analyses of human blood plasma spiked with alprazolam on the LCMS-8060NX and plotted the resulting area values and area ratios (internal standard material: alprazolam-d5). To evaluate the robustness under even more demanding conditions, we performed a total of 15,000 consecutive analyses without using valves to remove impurities. As shown in the data below, the results were extremely stable, with an area value reproducibility of 1.79 %RSD and an area ratio reproducibility of 1.71 %RSD. This demonstrates the excellent stability of results with the LCMS-8060NX even during consecutive analyses of samples with large amounts of contaminants such as urine and blood plasma.
Results from Consecutive Analyses of Alprazolam-Spiked Human Blood Plasma
LC/MS/MS Method Package and MRM Library
Designed for fast set-up in a range of support packages from pesticides to metabolic enzymes in wheat.
| Description | |
| Method package | Residual Pesticides |
| Veterinary Drugs | |
| Water Quality Analysis | |
| Drugs of Abuse | |
| Rapid Toxicology Screening | |
| Primary Metabolites | |
| Lipid Mediators | |
| Cell Culture Profilling | |
| MRM Library | Metabolic Enzymes in Yeast |
Application Specific LC-MS Systems
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The Forensic Toxicology Database includes optimized LC-MS/MS data acquisition parameters and a library database to help clinical and forensic researchers build screening and quantitation methods quickly, simplifying method development. -
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation? -
This MRM library includes two methods: one for phospholipid classification by comprehensive analysis of the main phospholipids in biological samples, and one for fatty acid composition determination created using analytical results obtained with the classification method. -
An enormous number of MRM conditions need to be evaluated in order to analyze a large number of proteins. -
Complete method for fast quantitative screening of 13 aminoglycosides in meat, eggs and milk. -
Of the short-chain fatty acids produced by intestinal bacteria, acetic acid, propionic acid, and butyric acid are well known, and it has been reported that there are some connections between them and lifestyle-related diseases such as obesity and diabetes. -
In recent years, while many issues have been raised related to food safety and the environment, the safety of textiles, which are indispensable for everyday life, has become a particular concern. -
Most important amino acids exist as stereoisomers. -
This system improves the efficiency of simultaneous LC/MS/MS analysis methods by allowing the user to start analysis without time-consuming steps such as consideration of separation conditions and MS parameter optimization. -
Database compatible with LabSolutions Connect, a tool that automates MRM tuning and optimization -
Shimadzu provides method files, including pre-registered MRM parameters with optimized quantitative and reference ions, LC separation parameters, and retention times and peak identification parameters for each compound, as well as report templates for outputting quantitation results, as a package. -
Method package including 129 veterinary drug compounds, more than 3 times as many as Ver. 1 -
This Method Package enables the analysis of 144 compounds in under 20 minutes per sample. -
Shimadzu Method Packages deliver conditions for efficient and simultaneous multi-component analysis. -
Lipid mediators (bioactive lipids) have important physiological functions and have been associated with allergies, thrombosis and lifestyle-related diseases. -
Provides procedures and methods for analyzing organofluorine compounds in drinking water according to EPA Methods 533 and 537.1 -
This LC/MS/MS Method Package for Reactive Sulfur Profiling offers analytical methods for LC/MS/MS that target all 17 sulfur-containing metabolites, including reactive sulfur species, with separation conditions and MS parameters that are optimized for each compound.
LC-MS Consumables
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This pretreatment kit for human biological samples is intended for the field of forensic medicine.
LC-MS Software
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It is reported glycans play an important role in physiology. -
Traverse MS data analysis software is intended for high-speed processing of MRM data acquired with Shimadzu triple quadrupole LCMS systems in the field of targeted metabolomics. -
Due to increasingly sophisticated automation, large quantities of high-quality mass spectrometer data can be obtained day and night. -
Optional software for the LC/MS/MS Method Packages for Primary Metabolites and Cell Culture Profiling
LabSolutions Series
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LabSolutions CS features an innovative operating environment and provides complete data management to ensure secure information in networked laboratories. -
LabSolutions DB has a data management function and is compliant with the ER/ES Regulations. It is optimally configured for customers using a PC.
Software Options
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LabSolutions Insight Library Screening is optional software for LabSolutions Insight. -
LabSolutions Connect can perform everything from execution of the optimization of MRM transitions and interface parameters to checking of the optimization results, creation of method and batch files for quantitative analysis, and quantitative calculations.
Related information
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The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. -
The LCMS-8045 was designed to be robust. The heated ESI probe, high-temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity and minimize contamination. -
LCMS-8040 incorporates newly improved ion optics and collision cell technology to provide higher multiple reaction monitoring (MRM) sensitivity. -
The LCMS-8060NX is a triple quadrupole mass spectrometer with world-class sensitivity and detection speeds. It boasts increased robustness and ease of use as well as Analytical Intelligence to maximize your laboratory’s output. -
nSMOL (nano-surface and molecular orientation limited proteolysis) is Shimadzu’s proprietary, innovative technique that enables selective proteolysis of the Fab region of monoclonal antibodies. -
Exact Mass Database for Endogenous Metabolites contains multiple ready-to-use methods for comprehensive analysis of metabolites with different properties. It is based on the successful LC/MS/MS Method Packages for Primary Metabolites, Cell Culture Profiling, Lipid Mediators, Short Chain Fatty Acids, and Bile Acids, and provides a comprehensive list of 470 metabolites with retention times and exact mass information. -
Triple quadrupole mass spectrometry (TQMS) is a versatile tool for quantitative analysis. Experience the excellent performance and robustness of Shimadzu’s LCMS-TQ instruments, which offer a choice of speed, sensitivity and resolution to meet the demands of high-throughput routine analysis and/or more specialized applications.
Compare Shimadzu’s triple quadrupole LC-MS/MS systems below.
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The Multi-omics Analysis Package, developed for metabolic engineering applications, provides the ability to automatically generate metabolic maps and perform a variety of data analysis for the vast data generated in fields like metabolomics, proteomics and flux analysis. -
This Method Package allows comprehensive analysis of 49 Bile Acids from plasma, urine and feces. Bile Acids are essential for cholesterol metabolism and play a key role in absorption of fats in the small intestine. Additionally, they serve as signaling molecules that regulate metabolism. -
Provides Sample Preparation Protocols and Analytical Methodsfor Glycosaminoglycans that Cause Mucopolysaccharidosis