Nexera Prep

Preparative Purification Liquid Chromatograph

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Easy optimization of preparative parameters and scale up
Fractionation simulation for rapid setup of collection logic Column line-up for scale-up from analytical to preparative
Time- and energy-saving by automation of the purification workflow
Collection of target components at high purity by automated desalting
Expandable to suit the sample/fraction number and volume
Choose from a wide range of options for recovery scale and analytical detection Problems are resolved simply, to accommodate a variety of needs.

Nexera, Open Solution, Shim-pack Scepter, LabSolutions and Purication Solution are trademarks of Shimadzu Corporation or its affiliated companies in Japan and/or other countries.

Features

Streamline and Simplify Establishing the Conditions for Preparative Work

Using the Nexera™ Prep system saves on labor when scaling up from the development of analytical conditions to the conditions for preparative work.
Preparative Work for Target Components at High Purity Levels and High Concentrations

The Shimadzu UFPLC, Ultra Fast Preparative and Purification Liquid Chromatograph significantly reduces the cost and labor involved in preparative purification. Additionally, the system not only performs purification of target components, but can also recover impurities with high yield enabling direct impurity analysis.
Preparative Work for Non-UV Absorptive Components

With LH-40 and FRC-40 able to perform signal-based logic and collection on up to four signal channels, not having a chromophore is not a limitation. Nexera Prep can use LCMS, RID, and ELSD to detect and/or identify targets for purification.
Increased Efficiency from Preparative Analysis Setup to Data Processing

Open Solution is open access software that not only streamlines preparative purification operations, but also supports multi-user operation of preparative systems.
High Separation via Preparative Recycling

By repeatedly cycling the sample through the column, the target component can be resolved and recovered from coeluting species or impurities without the need for longer or multiple columns.
Excellent System Expandability

The solvent delivery unit and fraction collector can be selected to suit the recovery volume. Sample introduction and reinjection options cover a wide range of uses. Additionally, the Shim-pack™ Scepter columns feature excellent scalability from analytical to preparative separations with a variety of phases for different applications.

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Latest Webinar

March 3, 2022

LC Purification Series Session 3 - Semi-Preparative Scale LC Purification-

Liquid Chromatography

HPLC/UHPLC/SFC Systems

Preparative HPLC Systems

1. Principles, common issues and tips and tricks of semi-preparative chromatography 2. UFPLC-Ultra fast preparative and purification LC 3. Semi-preparative SFC scale purification

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Videos

Carotene Purification from Carrots using Shimadzu Preparative HPLC with Liquid Handler LH-40

Preparative HPLC Systems

Purification of nutrients from food can be automatically done by Shimadzu preparative HPLC. This demo video shows how to purify carotene, one crucial carotenoid, from carrots. Ethanol is used to extract carotene from homogenized carrot samples. After centrifugation or filtration, the extract can be directly injected into a Shimadzu preparative HPLC system via a liquid handler (LH-40) for analysis and fraction collection. LH-40 is part of the system and is capable of conducting sample injection, fraction collection and sample re-injection. Manual fractionation, time program fractionation and peak integration fractionation are three fraction collection methods. The simulation function of LH-40 helps users to conveniently set fraction collection parameters. With Shimadzu preparative HPLC, targeted components of a sample can be easily and precisely separated and collected.

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