LCMS-9050

The LCMS-9050 is a Q-TOF mass spectrometer designed for the most reliable and easy acquisition of accurate masses in the real laboratory settings. With the proprietary innovation for fast polarity switching, it has the unique capability for high-confidence identification of challenging compounds and high-throughput screening of multiple unknowns. All sorts of applications are possible by the abundance of optional accessories and front-end configurations that leverage the instrument power. With the LCMS-9050, Shimadzu introduces a new era in time-of-flight mass spectrometry and continues Shimadzu’s tradition of taking on new challenges in LCMS.

Various LC-MS systems are used today, such as LC-MS single quadrupole system, LC-MS/MS triple quadrupole system and LC - quadrupole - time of flight, abbreviated as LC-Q-TOF system, and so on. This video introduces the features, advantages and applications in solving analytical problems of the different LC-MS systems. Taking sulfamerazine as an example, it explains from the ionization to mass spectra of the compound measured on the three types of LC-MS. LC-MS single quadrupole is used mainly for confirmation and quantitation in scan mode and/or SIM mode. LC-MS/MS triple quadruple can be operated in multiple modes such as Multiple Reaction Monitoring (MRM) and product ion scan etc. due to the QqQ configuration. It is particularly important in quantitation of trace level compounds by MRM mode method. While high resolution LC-Q-TOF provides the capability of measuring accurate masses of compounds in MS and MS/MS modes. The combination of accurate mass and MS/MS spectrum made it powerful in identification of unknown compounds and structural elucidation study. The latest models of LC-MS from Shimadzu are LCMS-2050, LCMS-8060NX and LCMS-9050, which have a common feature – ultrafast mass spectrometry or UFMS. This unique feature benefits greatly screening analysis for many targeted or un-targeted compounds such as pesticides, metabolites and toxicological compounds etc. with assistance of data analysis software.

Per and Polyfluorinated Alkyl Substances or PFAS are manufactured and used in industries, consumable products for several decades. In recent years, the uses of PFAS have been regulated, restricted or banned because they become the concern of public health due to wide-spread contamination. In this short video, we introduce how to screen and detect PFAS in food contact materials like paperboard and soft drink cup used in the fast restaurant. High resolution LC-Q-TOF mass spectrometry is used for non-targeted screening analysis of PFAS in data independent acquisition (DIA) method. Data analysis of such complex data is carried out using advanced software for precursor deconvolution, formula predictor, MS/MS library search, database search and fragment assign.