This pretreatment kit for human biological samples is intended for the field of forensic medicine.
LCMS-9030 - Options
Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer
Ionization Units
In addition to the standard ESI ionization unit, optional APCI and Dual Ion Source (DUIS) probes are available for the LCMS-9030 to meet various analytical needs. Shimadzu's DUIS offers an efficient combination of ESI and APCI ionization capabilities.
ESI (standard)
APCI (optional)
DUIS™ (optional)
The dual ion source continuously performs both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI).
Calibrant Delivery System (CDS)
The CDS allows calibration standards to be introduced via a separate ionization probe that functions independently from the main probe. This optional sub-ionization unit is installed in the main probe housing and is available for all probe types (ESI/APCI/DUIS). By having two probes in one system, high-concentration calibration standards can be introduced only when needed without switching flow lines, and are kept in isolation from the sample stream, eliminating contamination.
Micro-ESI 9030 Micro-flow Ionization Unit
Shimadzu’s Nexera Mikros microflow system combines the sensitivity improvements you expect from a low-flow system with the ruggedness of HPLC. Designed for optimal sensitivity and ease of use, the Micro-ESI 9030 interface brings microflow analysis to the Q-TOF. Ionization efficiency and transfer have been maximized by the probe design, resulting in high sensitivity, stable operation, and minimal contamination. To minimize dead volume and diffusion, the Nexera Mikros features an innovative snap-in column locking system, the UF-Link™, allowing any user to correctly install a microflow column without disrupting the ESI spray needle position. Realize the benefits of microflow while enjoying the reliability of HPLC.
Nexera Mikros & Micro-ESI 9030 System
View from the Top of the Instrument
iMScopeTM QT
The iMScope QT boasts not only fusion with morphology studies but also excellent speed, sensitivity, and spatial resolution, clearing the way to next-generation mass spectrometry imaging.
LabSolutions Insight Explore
Software for Both Qualitative and Quantitative Analysis
LabSolutions Insight Explore supports multi-sample, multi-component quantitative analysis as well as MS/MS library searches, structural analysis, formula prediction and charge state deconvolution, maximizing the potential of the High-resolution accurate mass data produced by the Q-TOF.
Structural Analysis Tool “Assign”
Compounds with the same chemical composition cannot be distinguished using MS chromatograms even when using high-resolution accurate mass data. Such substances can be identified with confidence by combining library searching and structural analysis using Assign. In the example below, MBDB and MDEA both have the chemical formula “C12H17NO2” (m/z 208.1332).
Component Detection Tool “Analyze”
Component detection tool “Analyze” can be used to identify unknown components in a sample. The results can then be processed using other Explore tools to yield chemical formulae and structural information.
Multivalent Ion Analysis (Deconvolution)
For the deconvolution of multiple charge state envelopes produced by large molecules, such as proteins and oligonucleotides, LabSolutions Insight Explore CSD includes ReSpect™. This multivalent ion analysis algorithm from Positive Probability Ltd detects related multi-charged peaks and calculates the mass of the original species. Excellent mass accuracy was obtained in the example below.
Impurity Detection using UV/PDA Chromatograms
Using UV/PDA chromatograms alongside MS chromatograms allows for detection of impurities more reliably. MS and MS/MS spectra corresponding to the UV/PDA peaks can be extracted for further processing such as formula prediction and fragment analysis.
LCMS, UF-Qarray, UF-Lens, UFsweeper, UFaccumulation, UFgrating, UF-FlightTube, iRefTOF, DUIS, UF-Link and LabSolutions Insight are trademarks of Shimadzu Corporation.
LC-MS Consumables
LC-MS Software
-
Traverse MS data analysis software is intended for high-speed processing of MRM data acquired with Shimadzu triple quadrupole LCMS systems in the field of targeted metabolomics. -
Due to increasingly sophisticated automation, large quantities of high-quality mass spectrometer data can be obtained day and night. -
LabSolutions Insight Biologics is software for analyzing the characteristics of oligonucleotides using the LCMS-9030 or LCMS-9050 quadrupole time-of-flight type (Q-TOF) mass spectrometer.
Related information
-
nSMOL (nano-surface and molecular orientation limited proteolysis) is Shimadzu’s proprietary, innovative technique that enables selective proteolysis of the Fab region of monoclonal antibodies. -
Exact Mass Database for Endogenous Metabolites contains multiple ready-to-use methods for comprehensive analysis of metabolites with different properties. It is based on the successful LC/MS/MS Method Packages for Primary Metabolites, Cell Culture Profiling, Lipid Mediators, Short Chain Fatty Acids, and Bile Acids, and provides a comprehensive list of 470 metabolites with retention times and exact mass information. -
The DPiMS QT probe electrospray ionization kit is attached to a quadrupole time-of-flight MS. The probe allows extremely small sample volumes to be selected and introduced into the MS unit for analysis. The DPiMS QT is a direct ionization interface unit that makes it simple for users to switch to ESI.
-
The High Resolution Accurate Mass (HRAM) Library includes two MS/MS spectral libraries. Each library is built using two different separation conditions and is suitable for targeted or non-targeted screening of drugs of abuse, psychotropic drugs, pharmaceuticals, pesticides, and other compounds of toxicological interest. -
LabSolutions Insight Biologics is software for analyzing the characteristics of oligonucleotides using the LCMS-9030 or LCMS-9050 quadrupole time-of-flight type (Q-TOF) mass spectrometer.